Letter from Chris

Hi, Roy,

Researchers just published a paper in the journal Brain outlining a new form of dementia, called LATE (Limbic-predominant Age-related TDP-43 Encephalopathy) that may be significantly more common than Alzheimer’s disease.

They also found
that Alzheimer’s and LATE often occur together, and when they do, the
rate of cognitive decline is faster than it is with Alzheimer’s alone.

This is important new research, and I hope that it helps us to better understand and treat dementia and cognitive decline.

Yet I can’t help feeling disappointed whenever I read media coverage about Alzheimer’s and other forms of dementia.

The focus still
seems to be on understanding the mechanisms of the diseases and then
developing drugs that target those mechanisms—despite the fact that this
approach has failed miserably over the last 25 years.

Despite a quarter
century of effort and hundreds of millions of dollars spent on research
and drug discovery, we still don’t have a single drug that effectively
slows the progression of, much less reverses, Alzheimer’s and dementia.

And we probably never will.

I don’t say that because I’m a pessimist.

In fact, I’m optimistic about our ability to both prevent and treat Alzheimer’s and other forms of dementia like LATE.

I just don’t think that will happen with a single drug—or multiple drugs.

It will happen by
looking at these conditions through the lens of Functional Medicine:
understanding the diet, lifestyle, and behavior factors and core
pathologies (e.g., inflammation, toxic exposure, hormone imbalance,
etc.) that cause them in the first place.

This seems obvious
to you and me, but I didn’t see a single article in the recent media
coverage of LATE give more than lip service to the idea that we might
actually be able to address cognitive decline with anything other than a

We’ll get there. I’m already seeing a big shift in other areas of medicine and with other conditions, which is encouraging.

And we’ve got a
growing number of people like you who are educating themselves and
taking their health back into their own hands!

That is what will ultimately turn the tide.

In health,


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